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KMID : 0370220160600030107
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Yakhak Hoeji
2016 Volume.60 No. 3 p.107 ~ p.111
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Inhibitory Activities of 1,5-Diarylimidazole Derivatives with Methylthiophenyl Group against PGE2 Production
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Kwon Jae-Hyun
Park Hae-Il
Kim Sung-Soo
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Abstract
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Inhibitory activities of 1,5-diarylimidazole analogs with methylthiophenyl group on prostaglandin E2 (PGE2) production from LPS-treated RAW 264.7 cells, were evaluated and compared with those of the corresponding analogs with 4-methanesulfonylphenyl group. Among the tested nineteen analogs with methylthiophenyl group, fourteen analogs showed strong inhibitory activities (>88%) when compared with the reference compound NS-398, and fifteen analogs have similar inhibitory activities with those of parent analogs with 4-methanesulfonylphenyl group. Those results suggest that most of 1,5- diarylimidazole analogs with methanesulfonylphenyl group can be also active even after they are metabolized by reduction.
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KEYWORD
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1,5-diarylimidazole, inflammation, 4-methylthiophenyl, prostaglandin E2
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